Tzanck cell

Definitions

(Noun) A degenerated epithelial cell from the keratin layer of the skin, disconnected from adjacent cells caused by acantholysis. It is seen in pemphigus.
See also Tzanck test.

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(Noun) Clumps of large hyperchromatic epithelial cells are seen lying free within the vesicular space formed as a result of acantholysis in the spinous layer of the epithelium. These are seen in Herpes Zooster, Varicella, Herpes Simplex virus, Pemphigus vulgaris, Cytomegalo virus.